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Target
sublocation: Introcelluar Protein.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP0177
|
| Target Name |
PTBP1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5725
|
| Gene ID |
100061673 (Equus caballus), 101092744 (Felis catus), 19205 (Mus musculus), 282018 (Bos taurus) 29497 (Rattus norvegicus), 485097 (Canis lupus familiaris), 5725 (Homo sapiens), 703430 (Macaca mulatta)
|
| Target Alternative Names |
57 kDa RNA-binding protein PPTB-1,HNRNP-I,HNRNPI,HNRPI,Heterogeneous nuclear ribonucleoprotein I (hnRNP I),PTB,PTB-1,PTB-T,PTB1,PTB2,PTB3,PTB4,PTBP1,Polypyrimidine tract-binding protein 1,Ptb,Ptbp1,Pybp,Pybp1,Pybp2,pPTB
|
| Uniprot Accession |
P17225,Q8WN55,Q00438,P26599
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000018845, ENSMUSG00000006498, ENSBTAG00000045828, ENSCAFG00845014619, ENSG00000011304, ENSMMUG00000016450
|
Pre-made viral vector of PTBP1 cDNA Clones/ORF Plasmid
PTBP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5725 | Pre-made Human PTBP1/PTB/PTB2 siRNA oligo Duplex | 5725 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29497 | Pre-made Rat Ptbp1/Ptb/PTB1 siRNA oligo Duplex | 29497 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19205 | Pre-made Mouse Ptbp1/Ptb/PTB2 siRNA oligo Duplex | 19205 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo703430 | Pre-made Cynomolgus/Rhesus macaque PTBP1 siRNA oligo Duplex | 703430 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092744 | Pre-made Cat/Feline PTBP1 siRNA oligo Duplex | 101092744 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485097 | Pre-made Dog/Canine PTBP1 siRNA oligo Duplex | 485097 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282018 | Pre-made Bovines/Cattle PTBP1/PTB siRNA oligo Duplex | 282018 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061673 | Pre-made Equine/Horse PTBP1 siRNA oligo Duplex | 100061673 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTBP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0177-Ab | Human | Anti-Human PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0177-Ab | Rat | Anti-Rat PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0177-Ab | Mouse | Anti-Mouse PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0177-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0177-Ab | Cat/Feline | Anti-Cat/Feline PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0177-Ab | Dog/Canine | Anti-Dog/Canine PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0177-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0177-Ab | Equine/Horse | Anti-Equine/Horse PTBP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PTBP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0177-Ag | Human | Human PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0177-Ag | Rat | Rat PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0177-Ag | Mouse | Mouse PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0177-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0177-Ag | Cat/Feline | Cat/Feline PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0177-Ag | Dog/Canine | Dog/Canine PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0177-Ag | Bovines/Cattle | Bovines/Cattle PTBP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0177-Ag | Equine/Horse | Equine/Horse PTBP1 recombinant protein | Mammalian cell | Detail |