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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP0119
|
| Target Name |
SF3B1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
23451
|
| Gene ID |
100070506 (Equus caballus), 101088016 (Felis catus), 23451 (Homo sapiens), 488456 (Canis lupus familiaris)
510177 (Bos taurus), 697773 (Macaca mulatta), 81898 (Mus musculus), 84486 (Rattus norvegicus)
|
| Target Alternative Names |
155kDa,2810001M05Rik,Hsh155,MDS,PRP10,PRPF10,Pre-mRNA-splicing factor SF3b 155 kDa subunit (SF3b155),Prp10,SAP155,SF3B1,SF3b155,Sap155,Sf3b1,Spliceosome-associated protein 155 (SAP 155),Splicing factor 3B subunit 1,TA-8,Targ4
|
| Uniprot Accession |
O75533,Q99NB9
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSECAG00000021657, ENSG00000115524, ENSCAFG00845026632, ENSBTAG00000008915, ENSMMUG00000022430, ENSMUSG00000025982
|
| Target Classification |
Tumor-associated antigen (TAA)
|
SF3B1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo23451 | Pre-made Human SF3B1/MDS/PRP10 siRNA oligo Duplex | 23451 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo84486 | Pre-made Rat Sf3b1/Sap155 siRNA oligo Duplex | 84486 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo81898 | Pre-made Mouse Sf3b1/TA-8/Prp10 siRNA oligo Duplex | 81898 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697773 | Pre-made Cynomolgus/Rhesus macaque SF3B1 siRNA oligo Duplex | 697773 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088016 | Pre-made Cat/Feline SF3B1 siRNA oligo Duplex | 101088016 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488456 | Pre-made Dog/Canine SF3B1 siRNA oligo Duplex | 488456 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510177 | Pre-made Bovines/Cattle SF3B1 siRNA oligo Duplex | 510177 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070506 | Pre-made Equine/Horse SF3B1 siRNA oligo Duplex | 100070506 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
SF3B1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0119-Ab | Human | Anti-Human SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0119-Ab | Rat | Anti-Rat SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0119-Ab | Mouse | Anti-Mouse SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0119-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0119-Ab | Cat/Feline | Anti-Cat/Feline SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0119-Ab | Dog/Canine | Anti-Dog/Canine SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0119-Ab | Bovines/Cattle | Anti-Bovines/Cattle SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0119-Ab | Equine/Horse | Anti-Equine/Horse SF3B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
SF3B1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0119-Ag | Human | Human SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0119-Ag | Rat | Rat SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0119-Ag | Mouse | Mouse SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0119-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0119-Ag | Cat/Feline | Cat/Feline SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0119-Ag | Dog/Canine | Dog/Canine SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0119-Ag | Bovines/Cattle | Bovines/Cattle SF3B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0119-Ag | Equine/Horse | Equine/Horse SF3B1 recombinant protein | Mammalian cell | Detail |
