Explore MBTPS1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
| Target ID |
GM-IP0112
|
| Target Name |
MBTPS1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8720
|
| Gene ID |
100055849 (Equus caballus), 101081852 (Felis catus), 489684 (Canis lupus familiaris), 511682 (Bos taurus) 56453 (Mus musculus), 714706 (Macaca mulatta), 8720 (Homo sapiens), 89842 (Rattus norvegicus)
|
| Target Alternative Names |
0610038M03Rik,Endopeptidase S1P,MBTPS1,Mbtps1,Membrane-bound transcription factor site-1 protease,PCSK8,S1P,S1p,SEDKF,SKI-1,Ski-1,Ski1,Subtilisin/kexin-isozyme 1 (SKI-1),mKIAA0091
|
| Uniprot Accession |
Q9WTZ2,Q14703,Q9WTZ3
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Protein processing in endoplasmic reticulum
|
| Gene Ensembl |
ENSECAG00000010283, ENSCAFG00845016031, ENSBTAG00000010170, ENSMUSG00000031835, ENSMMUG00000020053, ENSG00000140943
|
MBTPS1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8720 | Pre-made Human MBTPS1/S1P/PCSK8 siRNA oligo Duplex | 8720 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo89842 | Pre-made Rat Mbtps1/S1p/Ski-1 siRNA oligo Duplex | 89842 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56453 | Pre-made Mouse Mbtps1/S1P/Ski1 siRNA oligo Duplex | 56453 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714706 | Pre-made Cynomolgus/Rhesus macaque MBTPS1 siRNA oligo Duplex | 714706 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081852 | Pre-made Cat/Feline MBTPS1 siRNA oligo Duplex | 101081852 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo489684 | Pre-made Dog/Canine MBTPS1 siRNA oligo Duplex | 489684 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511682 | Pre-made Bovines/Cattle MBTPS1 siRNA oligo Duplex | 511682 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055849 | Pre-made Equine/Horse MBTPS1 siRNA oligo Duplex | 100055849 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
MBTPS1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0112-Ab | Human | Anti-Human MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0112-Ab | Rat | Anti-Rat MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0112-Ab | Mouse | Anti-Mouse MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0112-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0112-Ab | Cat/Feline | Anti-Cat/Feline MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0112-Ab | Dog/Canine | Anti-Dog/Canine MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0112-Ab | Bovines/Cattle | Anti-Bovines/Cattle MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0112-Ab | Equine/Horse | Anti-Equine/Horse MBTPS1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MBTPS1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0112-Ag | Human | Human MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0112-Ag | Rat | Rat MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0112-Ag | Mouse | Mouse MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0112-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0112-Ag | Cat/Feline | Cat/Feline MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0112-Ag | Dog/Canine | Dog/Canine MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0112-Ag | Bovines/Cattle | Bovines/Cattle MBTPS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0112-Ag | Equine/Horse | Equine/Horse MBTPS1 recombinant protein | Mammalian cell | Detail |