Explore UBA3 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IP0104
|
| Target Name |
UBA3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9039
|
| Gene ID |
100053395 (Equus caballus), 101090175 (Felis catus), 117553 (Rattus norvegicus), 22200 (Mus musculus)
476560 (Canis lupus familiaris), 512647 (Bos taurus), 696493 (Macaca mulatta), 9039 (Homo sapiens)
|
| Target Alternative Names |
A830034N06Rik,NAE2,NEDD8-activating enzyme E1 catalytic subunit,NEDD8-activating enzyme E1C,UBA3,UBE1C,Uba3,Ube1c,Ubiquitin-activating enzyme E1C,Ubiquitin-like modifier-activating enzyme 3 (Ubiquitin-activating enzyme 3),hUBA3
|
| Uniprot Accession |
Q99MI7,Q8C878,Q8TBC4
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000009659, ENSMUSG00000030061, ENSCAFG00845010556, ENSBTAG00000015556, ENSMMUG00000008620, ENSG00000144744
|
UBA3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9039 | Pre-made Human UBA3/NAE2/UBE1C siRNA oligo Duplex | 9039 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo117553 | Pre-made Rat Uba3/Ube1c siRNA oligo Duplex | 117553 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22200 | Pre-made Mouse Uba3/Ube1c/A830034N06Rik siRNA oligo Duplex | 22200 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696493 | Pre-made Cynomolgus/Rhesus macaque UBA3 siRNA oligo Duplex | 696493 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090175 | Pre-made Cat/Feline UBA3 siRNA oligo Duplex | 101090175 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476560 | Pre-made Dog/Canine UBA3/UBE1C siRNA oligo Duplex | 476560 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512647 | Pre-made Bovines/Cattle UBA3/UBE1C siRNA oligo Duplex | 512647 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100053395 | Pre-made Equine/Horse UBA3 siRNA oligo Duplex | 100053395 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
UBA3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0104-Ab | Human | Anti-Human UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0104-Ab | Rat | Anti-Rat UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0104-Ab | Mouse | Anti-Mouse UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0104-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0104-Ab | Cat/Feline | Anti-Cat/Feline UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0104-Ab | Dog/Canine | Anti-Dog/Canine UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0104-Ab | Bovines/Cattle | Anti-Bovines/Cattle UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0104-Ab | Equine/Horse | Anti-Equine/Horse UBA3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
UBA3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0104-Ag | Human | Human UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0104-Ag | Rat | Rat UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0104-Ag | Mouse | Mouse UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0104-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0104-Ag | Cat/Feline | Cat/Feline UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0104-Ag | Dog/Canine | Dog/Canine UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0104-Ag | Bovines/Cattle | Bovines/Cattle UBA3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0104-Ag | Equine/Horse | Equine/Horse UBA3 recombinant protein | Mammalian cell | Detail |
