Explore TDO2/TDO gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
| Target ID |
GM-IP0088
|
| Target Name |
TDO2/TDO
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6999
|
| Gene ID |
100069524 (Equus caballus), 101090935 (Felis catus), 475476 (Canis lupus familiaris), 530397 (Bos taurus)
56720 (Mus musculus), 64206 (Rattus norvegicus), 699739 (Macaca mulatta), 6999 (Homo sapiens)
|
| Target Alternative Names |
3-dioxygenase,HYPTRP,TDO,TDO2,TO,TPH2,TRPO,TRPO),Tdo,Tdo2,Tryptamin 2,Tryptophan 2,Tryptophan oxygenase (TO,Tryptophan pyrrolase,Tryptophanase,chky
|
| Uniprot Accession |
Q2KIQ5,P48776,P21643,P48775
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000020063, ENSCAFG00845010812, ENSBTAG00000011062, ENSMUSG00000028011, ENSMMUG00000022018, ENSG00000151790
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of TDO2/TDO cDNA Clones/ORF Plasmid
TDO2/TDO siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6999 | Pre-made Human TDO2/TO/TDO siRNA oligo Duplex | 6999 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64206 | Pre-made Rat Tdo2/TO/Tdo siRNA oligo Duplex | 64206 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo56720 | Pre-made Mouse Tdo2/TO/TDO siRNA oligo Duplex | 56720 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699739 | Pre-made Cynomolgus/Rhesus macaque TDO2 siRNA oligo Duplex | 699739 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090935 | Pre-made Cat/Feline TDO2 siRNA oligo Duplex | 101090935 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475476 | Pre-made Dog/Canine TDO2 siRNA oligo Duplex | 475476 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo530397 | Pre-made Bovines/Cattle TDO2/TRPO siRNA oligo Duplex | 530397 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069524 | Pre-made Equine/Horse TDO2 siRNA oligo Duplex | 100069524 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TDO2/TDO antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0088-Ab | Human | Anti-Human TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0088-Ab | Rat | Anti-Rat TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0088-Ab | Mouse | Anti-Mouse TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0088-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0088-Ab | Cat/Feline | Anti-Cat/Feline TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0088-Ab | Dog/Canine | Anti-Dog/Canine TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0088-Ab | Bovines/Cattle | Anti-Bovines/Cattle TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0088-Ab | Equine/Horse | Anti-Equine/Horse TDO2/TDO monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TDO2/TDO recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0088-Ag | Human | Human TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0088-Ag | Rat | Rat TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0088-Ag | Mouse | Mouse TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0088-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0088-Ag | Cat/Feline | Cat/Feline TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0088-Ag | Dog/Canine | Dog/Canine TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0088-Ag | Bovines/Cattle | Bovines/Cattle TDO2/TDO recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0088-Ag | Equine/Horse | Equine/Horse TDO2/TDO recombinant protein | Mammalian cell | Detail |
