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Target
sublocation: Introcelluar Protein.
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]
| Target ID |
GM-IP0077
|
| Target Name |
MAGEA4
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
4103
|
| Gene ID |
17140 (Mus musculus), 4103 (Homo sapiens), 710825 (Macaca mulatta)
|
| Target Alternative Names |
CT1.4,Cancer/testis antigen 1.4 (CT1.4),MAGE-4 antigen,MAGE-41,MAGE-41 antigen,MAGE-X2,MAGE-X2 antigen,MAGE4,MAGE4A,MAGE4B,MAGEA4,Mage-a4,Magea4,Melanoma-associated antigen 4
|
| Uniprot Accession |
P43358
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSMUSG00000033343, ENSG00000147381, ENSMMUG00000040274
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of MAGEA4 cDNA Clones/ORF Plasmid
MAGEA4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4103 | Pre-made Human MAGEA4/CT1.4/MAGE4 siRNA oligo Duplex | 4103 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17140 | Pre-made Mouse Magea4/Mage-a4 siRNA oligo Duplex | 17140 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo710825 | Pre-made Cynomolgus/Rhesus macaque MAGEA4 siRNA oligo Duplex | 710825 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
MAGEA4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0077-Ab | Human | Anti-Human MAGEA4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0077-Ab | Mouse | Anti-Mouse MAGEA4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0077-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque MAGEA4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
MAGEA4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0077-Ag | Human | Human MAGEA4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0077-Ag | Mouse | Mouse MAGEA4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0077-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque MAGEA4 recombinant protein | Mammalian cell | Detail |