Explore HSD11B1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]
| Target ID |
GM-IP0040
|
| Target Name |
HSD11B1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3290
|
| Gene ID |
100056429 (Equus caballus), 100529248 (Felis catus), 15483 (Mus musculus), 25116 (Rattus norvegicus)
282589 (Bos taurus), 3290 (Homo sapiens), 449023 (Canis lupus familiaris), 574322 (Macaca mulatta)
|
| Target Alternative Names |
11-DH,11-beta-HSD1,11-beta-hydroxysteroid dehydrogenase 1,11HSD1,7-oxosteroid reductase,CORTRD2,Corticosteroid 11-beta-dehydrogenase isozyme 1,HDL,HSD11,HSD11B,HSD11B1,HSD11L,Hsd11b1,LRRGT00065,SDR26C1,Short chain dehydrogenase/reductase family 26C member 1
|
| Uniprot Accession |
P50172,P16232,Q8HZJ8,P28845
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Chemical carcinogenesis - DNA adducts
|
| Gene Ensembl |
ENSECAG00000019243, ENSMUSG00000016194, ENSBTAG00000015086, ENSG00000117594, ENSCAFG00845002717, ENSMMUG00000059587
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HSD11B1 cDNA Clones/ORF Plasmid
HSD11B1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3290 | Pre-made Human HSD11B1/HDL/11-DH siRNA oligo Duplex | 3290 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25116 | Pre-made Rat Hsd11b1/LRRGT00065 siRNA oligo Duplex | 25116 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15483 | Pre-made Mouse Hsd11b1 siRNA oligo Duplex | 15483 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574322 | Pre-made Cynomolgus/Rhesus macaque HSD11B1 siRNA oligo Duplex | 574322 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100529248 | Pre-made Cat/Feline HSD11B1 siRNA oligo Duplex | 100529248 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo449023 | Pre-made Dog/Canine HSD11B1 siRNA oligo Duplex | 449023 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282589 | Pre-made Bovines/Cattle HSD11B1/11-DH/11HSD1 siRNA oligo Duplex | 282589 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100056429 | Pre-made Equine/Horse HSD11B1 siRNA oligo Duplex | 100056429 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
HSD11B1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IP0040-Ab | Human | Anti-Human HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-IP0040-Ab | Rat | Anti-Rat HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-IP0040-Ab | Mouse | Anti-Mouse HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IP0040-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-IP0040-Ab | Cat/Feline | Anti-Cat/Feline HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-IP0040-Ab | Dog/Canine | Anti-Dog/Canine HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IP0040-Ab | Bovines/Cattle | Anti-Bovines/Cattle HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-IP0040-Ab | Equine/Horse | Anti-Equine/Horse HSD11B1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
HSD11B1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IP0040-Ag | Human | Human HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-IP0040-Ag | Rat | Rat HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-IP0040-Ag | Mouse | Mouse HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-IP0040-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-IP0040-Ag | Cat/Feline | Cat/Feline HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-IP0040-Ag | Dog/Canine | Dog/Canine HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-IP0040-Ag | Bovines/Cattle | Bovines/Cattle HSD11B1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-IP0040-Ag | Equine/Horse | Equine/Horse HSD11B1 recombinant protein | Mammalian cell | Detail |
