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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
| Target ID |
GM-IO132
|
| Target Name |
SPAM1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
6677
|
| Gene ID |
101095731 (Felis catus), 475211 (Canis lupus familiaris), 6677 (Homo sapiens), 696249 (Macaca mulatta)
|
| Target Alternative Names |
HEL-S-96n,HYA1,HYAL1,HYAL3,HYAL5,Hyal-PH20,Hyaluronidase PH-20,Hyaluronoglucosaminidase PH-20,PH-20,PH20,SPAG15,SPAM1,Sperm adhesion molecule 1,Sperm surface protein PH-20
|
| Uniprot Accession |
P38567
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Metabolic pathways, Lysosome, Glycosaminoglycan degradation
|
| Gene Ensembl |
ENSCAFG00845005894, ENSG00000106304, ENSMMUG00000005719
|
| Target Classification |
Checkpoint-Immuno Oncology
|
SPAM1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6677 | Pre-made Human SPAM1/HYA1/PH20 siRNA oligo Duplex | 6677 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696249 | Pre-made Cynomolgus/Rhesus macaque SPAM1 siRNA oligo Duplex | 696249 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095731 | Pre-made Cat/Feline SPAM1 siRNA oligo Duplex | 101095731 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475211 | Pre-made Dog/Canine SPAM1 siRNA oligo Duplex | 475211 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
SPAM1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO132-Ab | Human | Anti-Human SPAM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IO132-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque SPAM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-IO132-Ab | Cat/Feline | Anti-Cat/Feline SPAM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-IO132-Ab | Dog/Canine | Anti-Dog/Canine SPAM1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
SPAM1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO132-Ag | Human | Human SPAM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-IO132-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque SPAM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-IO132-Ag | Cat/Feline | Cat/Feline SPAM1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-IO132-Ag | Dog/Canine | Dog/Canine SPAM1 VLP (virus-like particle) | HEK293 | Products Developing |
