Explore MICA/MICB gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Transmembrane Protein.
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
| Target ID |
GM-IO104
|
| Target Name |
MICA/MICB
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
100507436
|
| Gene ID |
100507436 (Homo sapiens), 119876843 (Canis lupus familiaris)
|
| Target Alternative Names |
MHC class I polypeptide-related sequence A,MIC-A,MICA,MICB,PERB11.1
|
| Uniprot Accession |
Q29983
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Natural killer cell mediated cytotoxicity, Kaposi sarcoma-associated herpesvirus infection
|
| Gene Ensembl |
ENSG00000204520
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of MICA/MICB cDNA Clones/ORF Plasmid
MICA/MICB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo100507436 | Pre-made Human MICA/MIC-A/PERB11.1 siRNA oligo Duplex | 100507436 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119876843 | Pre-made Dog/Canine MICA siRNA oligo Duplex | 119876843 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
MICA/MICB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO104-Ab | Human | Anti-Human MICA/MICB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-IO104-Ab | Dog/Canine | Anti-Dog/Canine MICA/MICB monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
MICA/MICB VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO104-Ag | Human | Human MICA/MICB VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-IO104-Ag | Dog/Canine | Dog/Canine MICA/MICB VLP (virus-like particle) | HEK293 | Products Developing |
