Explore IL-12RB1/CD212/IL12RB1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
| Target ID |
GM-IO073
|
| Target Name |
IL-12RB1/CD212/IL12RB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3594
|
| Gene ID |
100146965 (Equus caballus), 101093085 (Felis catus), 16161 (Mus musculus), 171333 (Rattus norvegicus)
3594 (Homo sapiens), 484828 (Canis lupus familiaris), 524299 (Bos taurus), 574199 (Macaca mulatta)
|
| Target Alternative Names |
CD212,IL-12 receptor beta component,IL-12 receptor subunit beta-1,IL-12R,IL-12R subunit beta-1,IL-12R-BETA1,IL-12R-beta-1,IL-12RB1,IL-12R[b],IL12RB,IL12RB1,IMD30,Il12rb,Il12rb1,Interleukin-12 receptor subunit beta-1
|
| Uniprot Accession |
Q60837,P42701
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Pathways in cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000021961, ENSMUSG00000000791, ENSG00000096996, ENSCAFG00845024036, ENSBTAG00000011481, ENSMMUG00000012096
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
IL-12RB1/CD212/IL12RB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3594 | Pre-made Human IL12RB1/CD212/IMD30 siRNA oligo Duplex | 3594 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo171333 | Pre-made Rat Il12rb1/Il12rb siRNA oligo Duplex | 171333 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16161 | Pre-made Mouse Il12rb1/CD212/IL-12R[b] siRNA oligo Duplex | 16161 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574199 | Pre-made Cynomolgus/Rhesus macaque IL12RB1/IL-12R siRNA oligo Duplex | 574199 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093085 | Pre-made Cat/Feline IL12RB1 siRNA oligo Duplex | 101093085 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo484828 | Pre-made Dog/Canine IL12RB1 siRNA oligo Duplex | 484828 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo524299 | Pre-made Bovines/Cattle IL12RB1 siRNA oligo Duplex | 524299 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146965 | Pre-made Equine/Horse IL12RB1 siRNA oligo Duplex | 100146965 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-12RB1/CD212/IL12RB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO073-Ab | Human | Anti-Human IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-IO073-Ab | Rat | Anti-Rat IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-IO073-Ab | Mouse | Anti-Mouse IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-IO073-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-IO073-Ab | Cat/Feline | Anti-Cat/Feline IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-IO073-Ab | Dog/Canine | Anti-Dog/Canine IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-IO073-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-IO073-Ab | Equine/Horse | Anti-Equine/Horse IL-12RB1/CD212/IL12RB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
IL-12RB1/CD212/IL12RB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO073-Ag | Human | Human IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-IO073-Ag | Rat | Rat IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-IO073-Ag | Mouse | Mouse IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-IO073-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-IO073-Ag | Cat/Feline | Cat/Feline IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-IO073-Ag | Dog/Canine | Dog/Canine IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-IO073-Ag | Bovines/Cattle | Bovines/Cattle IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-IO073-Ag | Equine/Horse | Equine/Horse IL-12RB1/CD212/IL12RB1 VLP (virus-like particle) | HEK293 | Products Developing |
