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Target
sublocation: Transmembrane Protein.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
| Target ID |
GM-IO025
|
| Target Name |
CLDN6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
9074
|
| Gene ID |
100065839 (Equus caballus), 101100433 (Felis catus), 287098 (Rattus norvegicus), 490048 (Canis lupus familiaris) 511318 (Bos taurus), 54419 (Mus musculus), 699854 (Macaca mulatta), 9074 (Homo sapiens)
|
| Target Alternative Names |
CLDN6,Claudin-6,Cldn6,Skullin
|
| Uniprot Accession |
Q9Z262,P56747
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C
|
| Gene Ensembl |
ENSECAG00000021500, ENSBTAG00000045901, ENSMUSG00000023906, ENSMMUG00000041201, ENSG00000184697
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CLDN6 cDNA Clones/ORF Plasmid
CLDN6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9074 | Pre-made Human CLDN6 siRNA oligo Duplex | 9074 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo287098 | Pre-made Rat Cldn6 siRNA oligo Duplex | 287098 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54419 | Pre-made Mouse Cldn6 siRNA oligo Duplex | 54419 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699854 | Pre-made Cynomolgus/Rhesus macaque CLDN6 siRNA oligo Duplex | 699854 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101100433 | Pre-made Cat/Feline CLDN6 siRNA oligo Duplex | 101100433 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490048 | Pre-made Dog/Canine CLDN6 siRNA oligo Duplex | 490048 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo511318 | Pre-made Bovines/Cattle CLDN6 siRNA oligo Duplex | 511318 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065839 | Pre-made Equine/Horse CLDN6 siRNA oligo Duplex | 100065839 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CLDN6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO025-Ab | Human | Anti-Human CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-IO025-Ab | Rat | Anti-Rat CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-IO025-Ab | Mouse | Anti-Mouse CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IO025-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-IO025-Ab | Cat/Feline | Anti-Cat/Feline CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-IO025-Ab | Dog/Canine | Anti-Dog/Canine CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IO025-Ab | Bovines/Cattle | Anti-Bovines/Cattle CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-IO025-Ab | Equine/Horse | Anti-Equine/Horse CLDN6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CLDN6 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO025-Ag | Human | Human CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-IO025-Ag | Rat | Rat CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-IO025-Ag | Mouse | Mouse CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-IO025-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-IO025-Ag | Cat/Feline | Cat/Feline CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-IO025-Ag | Dog/Canine | Dog/Canine CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-IO025-Ag | Bovines/Cattle | Bovines/Cattle CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-IO025-Ag | Equine/Horse | Equine/Horse CLDN6 VLP (virus-like particle) | HEK293 | Products Developing |