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Target
sublocation: Transmembrane Protein.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
| Target ID |
GM-IO024
|
| Target Name |
Claudin 3/CLDN3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1365
|
| Gene ID |
100059922 (Equus caballus), 105261291 (Felis catus), 12739 (Mus musculus), 1365 (Homo sapiens) 403648 (Canis lupus familiaris), 404153 (Bos taurus), 65130 (Rattus norvegicus), 716771 (Macaca mulatta)
|
| Target Alternative Names |
C7orf1,CLDN3,CPE-R2,CPE-receptor 2),CPETR2,Claudin 3,Claudin-3,Cldn3,Clostridium perfringens enterotoxin receptor 2 (CPE-R 2,Cpetr2,HRVP1,RVP1,Rat ventral prostate.1 protein homolog (hRVP1),claudin-3,mRVP1
|
| Uniprot Accession |
Q9Z0G9,O15551,Q95KM5,Q765N9,Q63400
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, Perinatal necrotizing enterocolitis, ovarian cancer
|
| Disease from KEGG |
Cell adhesion molecules, Tight junction, Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Hepatitis C
|
| Gene Ensembl |
ENSECAG00000057944, ENSMUSG00000070473, ENSG00000165215, ENSCAFG00845003145, ENSBTAG00000040432, ENSMMUG00000001143
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of Claudin 3/CLDN3 cDNA Clones/ORF Plasmid
Claudin 3/CLDN3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1365 | Pre-made Human CLDN3/RVP1/HRVP1 siRNA oligo Duplex | 1365 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo65130 | Pre-made Rat Cldn3 siRNA oligo Duplex | 65130 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12739 | Pre-made Mouse Cldn3/mRVP1/Cpetr2 siRNA oligo Duplex | 12739 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716771 | Pre-made Cynomolgus/Rhesus macaque CLDN3/claudin-3 siRNA oligo Duplex | 716771 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo105261291 | Pre-made Cat/Feline CLDN3 siRNA oligo Duplex | 105261291 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403648 | Pre-made Dog/Canine CLDN3/Claudin-3 siRNA oligo Duplex | 403648 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo404153 | Pre-made Bovines/Cattle CLDN3 siRNA oligo Duplex | 404153 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059922 | Pre-made Equine/Horse CLDN3 siRNA oligo Duplex | 100059922 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Claudin 3/CLDN3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-IO024-Ab | Human | Anti-Human Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-IO024-Ab | Rat | Anti-Rat Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-IO024-Ab | Mouse | Anti-Mouse Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-IO024-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-IO024-Ab | Cat/Feline | Anti-Cat/Feline Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-IO024-Ab | Dog/Canine | Anti-Dog/Canine Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-IO024-Ab | Bovines/Cattle | Anti-Bovines/Cattle Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-IO024-Ab | Equine/Horse | Anti-Equine/Horse Claudin 3/CLDN3 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Claudin 3/CLDN3 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-IO024-Ag | Human | Human Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-IO024-Ag | Rat | Rat Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-IO024-Ag | Mouse | Mouse Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-IO024-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-IO024-Ag | Cat/Feline | Cat/Feline Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-IO024-Ag | Dog/Canine | Dog/Canine Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-IO024-Ag | Bovines/Cattle | Bovines/Cattle Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-IO024-Ag | Equine/Horse | Equine/Horse Claudin 3/CLDN3 VLP (virus-like particle) | HEK293 | Products Developing |